[HTML][HTML] FOXC2 promotes vasculogenic mimicry and resistance to anti-angiogenic therapy

IG Cannell, K Sawicka, I Pearsall, SA Wild, L Deighton… - Cell Reports, 2023 - cell.com
Vasculogenic mimicry (VM) describes the formation of pseudo blood vessels constructed of
tumor cells that have acquired endothelial-like properties. VM channels endow the tumor …

[HTML][HTML] Structural and functional identification of vasculogenic mimicry in vitro

D Racordon, A Valdivia, G Mingo, R Erices… - Scientific Reports, 2017 - nature.com
Vasculogenic mimicry (VM) describes a process by which cancer cells establish an
alternative perfusion pathway in an endothelial cell-free manner. Despite its strong …

[HTML][HTML] Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation

B Zhao, M Wu, Z Hu, Y Ma, W Qi, Y Zhang… - Signal transduction and …, 2020 - nature.com
Tumor cells transform into endothelial cells by epithelial-to-mesenchymal transition, which is
characterized by vasculogenic mimicry (VM). VM not only accelerates tumor progression but …

[HTML][HTML] Nodal signaling promotes vasculogenic mimicry formation in breast cancer via the Smad2/3 pathway

W Gong, B Sun, X Zhao, D Zhang, J Sun, T Liu, Q Gu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Vasculogenic mimicry (VM) is a nonangiogenesis-dependent pathway that promotes tumor
growth and disease progression. Nodal signaling has several vital roles in both embryo …

[HTML][HTML] TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer

J Xu, X Yang, Q Deng, C Yang, D Wang… - Nature …, 2021 - nature.com
Enhanced neovasculogenesis, especially vasculogenic mimicry (VM), contributes to the
development of triple-negative breast cancer (TNBC). Breast tumor-initiating cells (BTICs) …

Antiangiogenesis therapy might have the unintended effect of promoting tumor metastasis by increasing an alternative circulatory system

B Qu, L Guo, J Ma, Y Lv - Medical hypotheses, 2010 - Elsevier
Antiangiogenesis therapy is one of the most promising approaches to cancer treatment. Its
clinical success has come out but still too limited. Vascularization of tumor is a complex and …

[HTML][HTML] HIF-2α promotes the formation of vasculogenic mimicry in pancreatic cancer by regulating the binding of Twist1 to the VE-cadherin promoter

J Yang, DM Zhu, XG Zhou, N Yin, Y Zhang, ZX Zhang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Vasculogenic mimicry (VM) is a blood supply modality that occurs independently of
endothelial cell angiogenesis. Hypoxia and the epithelial-mesenchymal transition (EMT) …

Phosphorylation of EphA2 receptor and vasculogenic mimicry is an indicator of poor prognosis in invasive carcinoma of the breast

D Mitra, S Bhattacharyya, N Alam, S Sen… - Breast Cancer Research …, 2020 - Springer
Purpose The occurrence of vasculogenic mimicry (VM) and EphA2-mediated tumour
progression are associated with poor prognosis in various solid tumours. Here, we aimed to …

[HTML][HTML] Molecular mechanisms of Thrombospondin-2 modulates tumor vasculogenic mimicry by PI3K/AKT/mTOR signaling pathway

J Huang, C Wang, Y Hou, Y Tian, Y Li, H Zhang… - Biomedicine & …, 2023 - Elsevier
Vasculogenic mimicry (VM) differs from the classical tumor angiogenesis model. VM does
not depend on endothelial cells; instead, highly aggressive tumor cells mimic endothelial …

[HTML][HTML] Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

X Wei, Y Chen, X Jiang, M Peng, Y Liu, Y Mo, D Ren… - Molecular cancer, 2021 - Springer
Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …