Unraveling the role of ACE2, the binding receptor for SARS-CoV-2, in inflammatory bowel disease

M Ferreira-Duarte, MM Estevinho… - Inflammatory Bowel …, 2020 - academic.oup.com
Abstract Angiotensin-converting enzyme 2 (ACE2) has been highlighted for its role as a
receptor for SARS-CoV-2, responsible for the current COVID-19 pandemic. This review …

Altered intestinal ACE2 levels are associated with inflammation, severe disease, and response to anti-cytokine therapy in inflammatory bowel disease

AA Potdar, S Dube, T Naito, K Li, G Botwin… - Gastroenterology, 2021 - Elsevier
Background And Aims The host receptor for severe acute respiratory syndrome coronavirus
2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small bowel (SB). Our …

[HTML][HTML] Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy …

AA Potdar, S Dube, T Naito, G Botwin, T Haritunians… - medRxiv, 2020 - ncbi.nlm.nih.gov
Abstract Angiotensin-Converting Enzyme 2 (ACE2) has been identified as the host receptor
for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely …

Down-regulation of colonic ACE2 expression in patients with inflammatory bowel disease responding to anti-TNF therapy: implications for COVID-19

XZ Li, Y Qiu, L Jeffery, F Liu, R Feng, JS He… - Frontiers in …, 2021 - frontiersin.org
Background and Aims: Angiotensin-converting enzyme II (ACE2) is the key molecule for
understanding the pathophysiology of COVID-19. The risk of COVID-19 and impact of …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease

T Toyonaga, KC Araba, MM Kennedy, BP Keith… - Scientific Reports, 2021 - nature.com
The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly
expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's …

Expression of SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in the gut of patients with IBD

JF Burgueno, A Reich, H Hazime… - Inflammatory bowel …, 2020 - academic.oup.com
Background Patients with inflammatory bowel disease (IBD) have intestinal inflammation
and are treated with immune-modulating medications. In the face of the coronavirus disease …

[HTML][HTML] Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury

M Oz, DE Lorke - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The recent emergence of coronavirus disease-2019 (COVID-19) as a pandemic affecting
millions of individuals has raised great concern throughout the world, and the severe acute …

Repurposing of RAS-pathway mediated drugs for intestinal inflammation related diseases for treating SARS-CoV-2 infection

A Sinha, RG Vaggu, R Swain, S Patnaik - Current Microbiology, 2023 - Springer
Abstract Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is an emerging
zoonotic virus, which causes Coronavirus Disease 2019 (COVID-19). Entry of coronaviruses …

ACE2 contributes to the maintenance of mouse epithelial barrier function

W Yu, X Ou, X Liu, S Zhang, X Gao, H Cheng… - Biochemical and …, 2020 - Elsevier
Background The whole world was hit hard by the coronavirus disease-19 (COVID-19). Given
that angiotensin I converting enzyme 2 (ACE2) is the viral entry molecule, understanding …