Osteoarthritis (OA) is considered to be primarily a disease of the hyaline articular cartilage,
which secondarily affects subchondral bone and synovial membrane. The exact nature and …

Osteoarthritis (OA) has long been considered a “wear and tear” disease leading to loss of
cartilage. OA used to be considered the sole consequence of any process leading to …

Osteoarthritis (OA) is a slowly progressive degenerative disease characterized by gradual
loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage …

Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Although cartilage degeneration characterizes human osteoarthritis (OA), changes also
involve the participation of the synovial membrane and the subchondral bone. In this review …

Traditionally, osteoarthritis (OA) has been conceptualized as a disease whose central
pathologic feature is hyaline articular cartilage loss. More recently, OA has been relabeled …

Decades ago, osteoarthritis (OA) was considered as the sole consequence of a “tear and
wear” process of cartilage without any participation of joint cells from any joint tissues. This …

It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis
(OA) is multifactorial and involves the interactions between cartilage and its surrounding …

Osteoarthritis (OA) is characterized by a degeneration of articular cartilage, in which the
breakdown leads to matrix fibrillation, fissure appearance, gross ulceration, and fullthickness …

Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …