OBJECTIVE: To review the literature on the role and regulation of chondrocyte terminal
differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a …

OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

Publisher Summary This chapter focuses on the pathogenesis of rheumatoid arthritis. In an
infectious etiology of rheumatoid arthritis, it is pertinent to consider the manner in which a …

Osteoarthritis (OA) is one of the most common diseases among the elderly. For many years,
OA was considered a normal result of the aging process with few treatment options …

Ann Rheum Dis June 2012 Vol 71 No 6 794 play crucial roles. Syndycan-4 is even
suggested to constitute a novel target for the treatment of arthritic cartilage damage. Is that …

We studied 10 patients who had arthritis of the knee joint, but no other signs of rheumatic
disease. The clinical diagnosis of osteoarthritis was corroborated by arthroscopic evidence …

Osteoarthritis (OA) is a slowly progressive degenerative joint disorder characterized by
cartilage damage, changes in periarticular bone including osteophyte formation and a …

Although osteoarthritis (OA) was historically referred to as the non-inflammatory arthritis, it is
now considered a condition involving persistent low-grade inflammation and activation of …

Osteoarthritis (OA) has long been considered the unique consequence of a wear and tear
process leading to cartilage degradation. Indeed, it is true that excessive mechanical stress …

Objective. To define variations in the cellular infiltrate and in the expression of monokines in
synovial tissue (ST) from rheumatoid arthritis (RA) patients with different durations of disease …