HOMEOSTASIS of normal cartilage in adults represents a delicate balance between the
degradation and the synthesis of extra-cellular matrix components to maintain the functional …

Over the last decade, there have been several interesting advances in the treatment of
osteoarthritis (OA). A clearer understanding of the pathophysiology of this disease1 has …

Osteoarthritis-specific autoantigens may drive chronic synovitis and may thereby contribute
to production of cytokines to upregulate proteases, which lead to chondrocyte and cartilage …

The pathogenesis of osteoarthritis (OA) involves cartilage degradation, synovial
inflammation, subchondral bone sclerosis, degeneration of ligaments and meniscus, and …

The subtype of the proliferating cells in the synovial fluid of patients with rheumatoid arthritis
(RA), ankylopoietic spondylarthrosis (SPA), and osteoarthritis (OA) was studied with auto …

While the cartilage and bone abnormalities in osteoarthritis (OA) have been adequately
described there are few prospective reviews of the histopathologic changes in OA synovia …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Immunohistochemical double‐staining was performed on frozen sections from synovial
biopsies obtained at arthroscopy from 22 patients with different kinds of synovitis. Not only in …

OA is characterized by a degeneration of articular cartilage. Breakdown of the cartilage
matrix leads to the development of fibrillation, fissures, the appearance of gross ulcerations …

Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large
population worldwide and for which there is no definitive cure. This review provides critical …