Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

P Blume‐Jensen, A Siegbahn, S Stabel… - The EMBO …, 1993 - embopress.org
The product of the c‐kit proto‐oncogene, denoted Kit/SCF‐R, encodes a tyrosine kinase
receptor for stem cell factor (SCF). Kit/SCF‐R induces proliferation, differentiation or …

[HTML][HTML] Identification of the Major Phosphorylation Sites for Protein Kinase C in Kit/Stem Cell Factor Receptor in Vitro and in Intact Cells∗

P Blume-Jensen, C Wernstedt, CH Heldin… - Journal of Biological …, 1995 - ASBMB
The c-kit-encoded tyrosine kinase receptor for stem cell factor (Kit/SCFR) is crucial for the
development of hematopoietic cells, melanoblasts, and germ cells. Ligand stimulation of …

Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C.

P Blume-Jensen, L Rönnstrand, I Gout… - Journal of Biological …, 1994 - ASBMB
The Kit/stem cell factor receptor (Kit/SCF-R) is a transmembrane tyrosine kinase receptor of
importance for the normal development of hemopoietic cells, melanoblasts, and germ cells …

The c‐kit proto‐oncogene in normal and malignant human hematopoiesis

WZ Ratajczak, SM Luger… - The International Journal …, 1992 - Wiley Online Library
The c‐kit proto‐oncogene encodes a tyrosine kinase receptor (KIT) which is expressed on
many types of human cells, including‐4% of bone marrow mononuclear cells. Numerous …

[HTML][HTML] Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor.

JM Blechman, S Lev, MF Brizzi, O Leitner… - Journal of Biological …, 1993 - Elsevier
The binding of the stem cell factor (SCF) to the c-kit-encoded receptor tyrosine kinase
stimulates a variety of biochemical responses that culminate in cellular proliferation …

[HTML][HTML] The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

P Blume-Jensen, R Janknecht, T Hunter - Current biology, 1998 - cell.com
The c-kit-encoded receptor protein tyrosine kinase for stem cell factor (Kit/SCF-R) is
essential for the development of cells within the hematopoietic, melanogenic and …

Soluble c-kit receptor blocks stem cell factor bioactivity in vitro

DD Dahlen, NL Lin, YC Liu, VC Broudy - Leukemia research, 2001 - Elsevier
Stem cell factor (SCF) is a growth factor that promotes the survival, proliferation, and
differentiation of hematopoietic cells. SCF and its receptor, Kit, are normally present in both …

[HTML][HTML] Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.

S Lev, Y Yarden, D Givol - Journal of Biological Chemistry, 1992 - Elsevier
The protooncogene c-kit encodes a tyrosine kinase receptor for the stem cell factor (SCF).
Mutants of c-kit were shown to confer a pleiotropic defective phenotype and often display …

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit …

T Furitsu, T Tsujimura, T Tono, H Ikeda… - The Journal of …, 1993 - Am Soc Clin Investig
The c-kit proto-oncogene encodes a receptor tyrosine kinase. Binding of c-kit ligand, stem
cell factor (SCF) to c-kit receptor (c-kitR) is known to activate c-kitR tyrosine kinase, thereby …

The biology of stem cell factor and its receptor C-kit

LK Ashman - The international journal of biochemistry & cell biology, 1999 - Elsevier
The receptor tyrosine kinase c-Kit and its ligand Stem Cell Factor (SCF) are essential for
haemopoiesis, melanogenesis and fertility. SCF acts at multiple levels of the haemopoietic …