Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat
African river blindness and African sleeping sickness. Suramin has also been extensively …

Suramin has been reported to inhibit the reverse transcriptase activity of a number of
retroviruses and to reduce the in vitro infectivity and cytopathic effect of HTLV‐III/LAV, the …

Suramin is a symmetric polyanionic naphthylurea originally used for the treatment of
trypanosomiasis and onchocerciasis. Suramin and diverse analogues exhibit a broad range …

Background Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes
high fever, rash, and recurrent arthritis in humans. It has efficiently adapted to Aedes …

Only four drugs are available for the chemotherapy of human African trypanosomiasis or
sleeping sickness; Suramin, pentamidine, melarsoprol and eflornithine. The history of the …

The concept of disease-specific chemotherapy was developed a century ago. Dyes and
arsenical compounds that displayed selectivity against trypanosomes were central to this …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes severe and often
persistent arthritis. In recent years, millions of people have been infected with this virus for …

Ehrlich's pioneering chemotherapeutic experiments published in 1904 (Ehrlich, P., and
Shiga, K.(1904) Berlin Klin. Wochenschrift 20, 329–362) described the efficacy of a series of …

The mosquito-borne Chikungunya virus (CHIKV) is a profound global threat due to its high
rate of contagion and the lack of vaccine or effective treatment. Suramin is a symmetric …