Increased prostaglandin (PG) production is associated with many inflammatory
pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes …

The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and
rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a …

Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has
attracted considerable attention recently, due to its role in human cancer biology. Several …

Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

Tumorigenesis is a complex process, and understanding the mechanisms behind
tumorigenesis is key to identifying effective targeted therapies. Prostaglandins are signaling …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …

Cancer is a major cause of death worldwide despite significant advances in surgery and
biology. Several recent studies have suggested that there is a close connection between …

Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs
(NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of …