[HTML][HTML] Immune checkpoints and innate lymphoid cells—new avenues for cancer immunotherapy
N Jacquelot, M Ghaedi, K Warner, DC Chung… - Cancers, 2021 - mdpi.com
Simple Summary Targeting the inhibitory receptors expressed by immune cells has
revolutionized the clinical management of cancer patients. Initially developed to enhance T …
revolutionized the clinical management of cancer patients. Initially developed to enhance T …
[HTML][HTML] Diversity of immune checkpoints in cancer immunotherapy
Z Guo, R Zhang, AG Yang, G Zheng - Frontiers in Immunology, 2023 - frontiersin.org
Finding effective treatments for cancer remains a challenge. Recent studies have found that
the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal …
the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal …
[HTML][HTML] Cancer immunotherapy by blocking immune checkpoints on innate lymphocytes
Simple Summary The emergence of immunotherapy for cancer treatment bears
considerable clinical promise. The role of NK cells in tumor immunosurveillance and their …
considerable clinical promise. The role of NK cells in tumor immunosurveillance and their …
[HTML][HTML] Perspectives on immune checkpoint ligands: expression, regulation, and clinical implications
J Moon, YM Oh, SJ Ha - BMB reports, 2021 - ncbi.nlm.nih.gov
In the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in
order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL …
order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL …
[HTML][HTML] Harnessing the immune system by targeting immune checkpoints: Providing new hope for Oncotherapy
With the goal of harnessing the host's immune system to provide long-lasting remission and
cures for various cancers, the advent of immunotherapy revolutionized the cancer therapy …
cures for various cancers, the advent of immunotherapy revolutionized the cancer therapy …
Regulatory mechanisms of inhibitory immune checkpoint receptors expression
N Curdy, O Lanvin, C Laurent, JJ Fournié… - Trends in cell …, 2019 - cell.com
T cells responding to persistent tumor or viral antigens progressively lose their functional
properties, a feature known as exhaustion. This state is also characterized by cell-surface …
properties, a feature known as exhaustion. This state is also characterized by cell-surface …
[HTML][HTML] Immune checkpoint signaling and cancer immunotherapy
Immune checkpoint blockade therapy has become a major weapon in fighting cancer.
Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such …
Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such …
[HTML][HTML] Cancer immunotherapy: a focus on the regulation of immune checkpoints
T Shi, Y Ma, L Yu, J Jiang, S Shen, Y Hou… - International journal of …, 2018 - mdpi.com
In recent years, the role of cancer immunotherapy has become increasingly important
compared to traditional cancer treatments, including surgery, chemotherapy and …
compared to traditional cancer treatments, including surgery, chemotherapy and …
Dawn era for revisited cancer therapy by innate immune system and immune checkpoint inhibitors
Immunotherapy is a promising therapeutic strategy for cancer. However, it shows limited
efficacy against certain tumor types. The activation of innate immunity can suppress tumors …
efficacy against certain tumor types. The activation of innate immunity can suppress tumors …
[HTML][HTML] Targets of immune escape mechanisms in cancer: basis for development and evolution of cancer immune checkpoint inhibitors
Simple Summary The tumor immune escape mechanisms are key factors in cancer
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …
progression and metastasis. They are an undeniable hurdle for successful cancer treatment …
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