One area that has emerged as a promising therapeutic target for the treatment and
prevention of chronic pain and opioid tolerance/hyperalgesia is the modulation of the central …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

It is recently become clear that activated immune cells and immune-like glial cells can
dramatically alter neuronal function. By increasing neuronal excitability, these non-neuronal …

Recent evidence implicates an adaptive immune response in the central nervous system
(CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters …

A recent plethora of studies has characterized a central nervous system (CNS)
neuroimmune response in animal models of persistent pain. This response, which may be …

A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …

Neuropathic pain represents a major problem in clinical medicine because it causes
debilitating suffering and is largely resistant to currently available analgesics. A …

Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …

Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

This review examines recently recognized roles of immunological processes in pain
modulation and explores the potential implications of these immunologically derived …