OBJECTIVES/SPECIFIC AIMS: Obesity is a rapidly growing epidemic and long-term
interventions aimed to reduce body weight are largely unsuccessful due to an increased …

Moderate weight loss improves numerous risk factors for cardiometabolic disease; however,
long-term weight loss maintenance (WLM) is often thwarted by metabolic adaptations that …

Transgenic (Tg) FVB/N mice were produced that overexpress human lipoprotein lipase
(LPL) in skeletal muscle using the muscle creatine kinase promoter and enhancers. It was …

Introduction Overexpression of lipoprotein lipase (LPL) protects against high-fat-diet (HFD)-
induced obesity and insulin resistance in transgenic rabbits; however, the molecular …

OBJECTIVE Skeletal muscle–specific LPL knockout mouse (SMLPL−/−) were created to
study the systemic impact of reduced lipoprotein lipid delivery in skeletal muscle on insulin …

Metabolic adaptations established during weight loss maintenance accelerate weight regain
by suppressing energy expenditure; therefore, interventions that increase energy …

Exercise is a potent strategy to facilitate long-term weight maintenance. In addition to
increasing energy expenditure and reducing appetite, exercise also favors the oxidation of …

Vascular lipases including lipoprotein lipase (LPL), hepatic lipase (HL) and endothelial
lipase (EL) are important determinants of plasma lipid homeostasis and coronary artery …

Skeletal muscle lipoprotein lipase (LPL) overexpression in mice results in whole-body
insulin resistance and increased intramuscular triglyceride stores, but decreased plasma …

Lipoprotein lipase (LPL) is a multifunctional enzyme produced by and studied in many
tissues, including adipose tissue, cardiac and skeletal muscle, islets, and macrophages …