The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous
impact on global health, causing 181,000 deaths annually. Current treatment options are …

Background Thermotolerance is an essential attribute for pathogenesis of Cryptococcus as
exemplified by the fact that only two species in the genus, which can grow at 37° C, are …

Cryptococcus gattii is one of the etiological agents of cryptococcosis. To achieve a
successful infection, C. gattii cells must overcome the inhospitable host environment and …

The pathogenic yeast Cryptococcus neoformans secretes numerous proteins, such as heat
shock proteins, by unconventional mechanisms during its interaction with host cells. Hsp70 …

The underlying mechanism of thermotolerance, which is a key virulence factor essential for
pathogenic fungi such as Cryptococcus neoformans, is largely unexplored. In this study, our …

Thermotolerance is a crucial virulence attribute for human pathogens, including the fungus
Cryptococcus neoformans that causes fatal meningitis in humans. Loss of the protein kinase …

The human fungal pathogen Cryptococcus neoformans relies on a complex signaling
network for the adaptation and survival at the host temperature. Protein phosphatase …

While research has identified an important contribution for metals, such as iron, in microbial
pathogenesis, the roles of other transition metals, such as copper, remain mostly unknown …

Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …

Upon Cryptococcus neoformans infection of the host lung, the fungus enters a nutrient poor
environment and must adapt to a variety of host-specific stress conditions (temperature …