Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes mellitus
NN Mehta - Circulation: Cardiovascular Genetics, 2012 - Am Heart Assoc
Mehta Genomics of Type 2 Diabetes 709 variants associated with body mass index (CEU
r2= 0.80) and triglyceride concentration (CEU r2= 0.84) and has been associated with waist …
r2= 0.80) and triglyceride concentration (CEU r2= 0.84) and has been associated with waist …
Shared genetic contribution of type 2 diabetes and cardiovascular disease: implications for prognosis and treatment
RJ Strawbridge, NR van Zuydam - Current Diabetes Reports, 2018 - Springer
Abstract Purpose of Review The increased cardiovascular disease (CVD) risk in subjects
with type 2 diabetes (T2D) is well established. This review collates the available evidence …
with type 2 diabetes (T2D) is well established. This review collates the available evidence …
Genetic susceptibility for coronary heart disease and type 2 diabetes complications
AZ Kalea, SC Harrison, JW Stephens… - Clinical …, 2012 - academic.oup.com
Type II diabetes (T2D) 3 represents a major public health challenge, with the WHO having
estimated a current prevalence of 346 million worldwide. Cardiovascular disease, including …
estimated a current prevalence of 346 million worldwide. Cardiovascular disease, including …
Current insights into the joint genetic basis of type 2 diabetes and coronary heart disease
M Dauriz, JB Meigs - Current cardiovascular risk reports, 2014 - Springer
The large-scale genome-wide association studies conducted so far identified numerous
allelic variants associated with type 2 diabetes (T2D), coronary heart disease (CHD) and …
allelic variants associated with type 2 diabetes (T2D), coronary heart disease (CHD) and …
Genome-wide association studies and type 2 diabetes
In recent years, the search for genetic determinants of type 2 diabetes (T2D) has changed
dramatically. Although linkage and small-scale candidate gene studies were highly …
dramatically. Although linkage and small-scale candidate gene studies were highly …
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
Abstract Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a
meta-analysis of genome-wide association studies (GWAS) with~ 16 million genetic variants …
meta-analysis of genome-wide association studies (GWAS) with~ 16 million genetic variants …
Genetics insights in the relationship between type 2 diabetes and coronary heart disease
MO Goodarzi, JI Rotter - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus is a major risk factor for coronary heart disease (CHD). The major form of
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …
Type 2 diabetes and genetics, 2010: translating knowledge into understanding
GA Walford, JC Florez - Current Cardiovascular Risk Reports, 2010 - Springer
Abstract Type 2 diabetes (T2D) is epidemic, but much has been learned about its molecular
etiology in recent years. In this review, we present the substantial evidence for the …
etiology in recent years. In this review, we present the substantial evidence for the …
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk
H Jansen, C Loley, W Lieb, MJ Pencina, CP Nelson… - Atherosclerosis, 2015 - Elsevier
Background The mechanisms underlying the association between diabetes and coronary
artery disease (CAD) risk are unclear. We aimed to assess this association by studying …
artery disease (CAD) risk are unclear. We aimed to assess this association by studying …
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …