The mRNA-destabilizing protein Tristetraprolin targets “meiosis arrester” Nppc mRNA in mammalian preovulatory follicles

G Xi, L An, W Wang, J Hao, Q Yang… - Proceedings of the …, 2021 - National Acad Sciences
C-natriuretic peptide (CNP) and its receptor guanylyl cyclase, natriuretic peptide receptor 2
(NPR2), are key regulators of cyclic guanosine monophosphate (cGMP) homeostasis. The …

[PDF][PDF] RETRACTED: Elevated Tristetraprolin Impairs Trophoblast Invasion in Women with Recurrent Miscarriage by Destabilization of HOTAIR

FJ Tian, XY He, J Wang, X Li, XL Ma, F Wu… - … Therapy-Nucleic Acids, 2018 - cell.com
Tristetraprolin (TTP) regulates the stability of multiple targets that have important biological
roles. However, the role of TTP in trophoblasts at the maternal-fetal interface remains poorly …

The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development

SBV Ramos, DJ Stumpo, EA Kennington, RS Phillips… - 2004 - journals.biologists.com
The CCCH tandem zinc finger protein, Zfp36l2, like its better-known relative tristetraprolin
(TTP), can decrease the stability of AU-rich element-containing transcripts in cell transfection …

Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo

WS Lai, DJ Stumpo, ML Wells, A Gruzdev… - … and cellular biology, 2019 - Taylor & Francis
Tristetraprolin (TTP) is an anti-inflammatory protein that modulates the stability of certain
cytokine/chemokine mRNAs. After initial high-affinity binding to AU-rich elements in 3 …

Tristetraprolin controls the stability of cIAP2 mRNA through binding to the 3′ UTR of cIAP2 mRNA

CW Kim, HK Kim, MT Vo, HH Lee, HJ Kim… - Biochemical and …, 2010 - Elsevier
cIAP2 is a key regulator of programmed cell death and the NF-κB pathway. Here, we
investigated the post-transcriptional regulation of cIAP2 expression by tristetraprolin (TTP) …

Chorioallantoic Fusion Defects and Embryonic Lethality Resulting from Disruption of Zfp36L1, a Gene Encoding a CCCH Tandem Zinc Finger Protein of the …

DJ Stumpo, NA Byrd, RS Phillips, S Ghosh… - … and cellular biology, 2004 - Taylor & Francis
The mouse gene Zfp36L1 encodes zinc finger protein 36-like 1 (Zfp36L1), a member of the
tristetraprolin (TTP) family of tandem CCCH finger proteins. TTP can bind to AU-rich …

mRNA Destabilizing Factors: Tristetraprolin Expression at the Porcine Maternal–Fetal Interface

K Khalaj, JM Wessels, RT Kridli… - American Journal of …, 2015 - Wiley Online Library
Problem To evaluate the expression of the tristetraprolin family and their selected targets
during porcine pregnancy. Method of study Using qPCR and Western blot, mRNA and …

Zfp36l3, a Rodent X Chromosome Gene Encoding a Placenta-Specific Member of the Tristetraprolin Family of CCCH Tandem Zinc Finger Proteins

PJ Blackshear, RS Phillips, S Ghosh… - Biology of …, 2005 - academic.oup.com
Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger (TZF) proteins can
bind directly to AU-rich elements (ARE) in mRNA, causing deadenylation and destabilization …

[HTML][HTML] hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay

B Reznik, SL Clement, J Lykke-Andersen - PLoS One, 2014 - journals.plos.org
The tristetraprolin (TTP) family of zinc-finger proteins, TTP, BRF1 and BRF2, regulate the
stability of a subset of mRNAs containing 3′ UTR AU-rich elements (AREs), including …

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements

R Fu, MT Olsen, K Webb, EJ Bennett… - Rna, 2016 - rnajournal.cshlp.org
The zinc finger protein tristetraprolin (TTP) promotes translation repression and degradation
of mRNAs containing AU-rich elements (AREs). Although much attention has been directed …