AU‐rich elements (AREs) in the 3′ untranslated region (UTR) of numerous mammalian
transcripts function as instability elements that promote rapid mRNA degradation …

The zinc finger protein 36-like 2, Zfp36l2, has been implicated in female mouse infertility,
because an amino-terminal truncation mutation (ΔN-Zfp36l2) leads to two-cell stage arrest of …

Tumor necrosis factor (TNF)-α is a major cytokine produced by alveolar macrophages in
response to pathogen-associated molecular patterns such as lipopolysaccharide. TNF-α …

Tristetraprolin (TTP) is a nucleocytoplasmic 326 amino acid protein whose sequence is
characterized by possessing two CCCH-type zinc finger domains. In the cytoplasm TTP …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

Tristetraprolin (TTP) is an mRNA-destabilizing protein that negatively regulates the
expression of proinflammatory mediators such as tumor necrosis factor α, granulocyte …

Simple Summary Chronic inflammatory diseases account for up to 60% of deaths worldwide
and, thus, are considered a great threat for human health by the World Health Organization …

The zinc-finger protein tristetraprolin (TTP) binds to AU-rich elements present in the 3′
untranslated regions of transcripts that mainly encode proteins of the inflammatory response …

For a successful yet controlled immune response, cells need to specifically destabilize
inflammatory mRNAs but prevent premature removal of those still used. The regulatory …

Tristetraprolin (TTP) is an RNA-binding protein that controls the inflammatory response by
limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally …