Messenger RNA decay is a critical mechanism to control the expression of many
inflammation-and cancer-associated genes. These transcripts are targeted for rapid …

Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its
rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice and cells derived …

Twenty years ago, the first description of a tristetraprolin (TTP) knockout mouse highlighted
the fundamental role of TTP in the restraint of inflammation. Since then, work from several …

The mitogen-activated protein kinase (MAPK) p38/MAPK-activated protein kinase 2 (MK2)
signaling pathway plays an important role in the posttranscriptional regulation of tumor …

The mRNA destabilizing factor tristetraprolin (TTP) functions as a tumor suppressor by down-
regulating cancer-associated genes. TTP expression is significantly reduced in various …

Tristetraprolin (TTP) is a CCCH zinc finger-containing protein that destabilizes mRNA by
binding to an AU-rich element. Mice deficient in TTP develop a severe inflammatory …

The differential expression of the critical cell cycle control proteins cyclin D1 and c-myc has
been shown to result in Akt-dependent hypersensitivity of tumor cells to mTOR inhibitors. We …

In developing ovarian follicles, the progesterone receptor (PGR) is essential for mediating
transcription of key factors that coordinate cellular functions including follicular remodeling …

The tristetraprolin (TTP) family of CCCH tandem zinc-finger proteins is composed of three
known members in mammals, with a fourth member recently identified in frogs and fish …

Members of the tristetraprolin family of tandem CCCH finger proteins can bind to AU-rich
elements in the 3′-untranslated region of mRNAs, leading to their deadenylation and …