Regulation of both erythroid and megakaryocytic differentiation of a human leukemia cell line, UT-7
Y Miura, K Kirito, N Komatsu - Acta haematologica, 1998 - karger.com
UT-7 is a human megakaryoblastic leukemia cell line with absolute dependence on
interleukin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), or erythropoietin …
interleukin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), or erythropoietin …
A novel function of Stat1α and Stat3 proteins in erythropoietin-induced erythroid differentiation of a human leukemia cell line
K Kirito, M Uchida, M Takatoku… - Blood, The Journal …, 1998 - ashpublications.org
We recently determined that erythropoietin (EPO) activates 3 members of the signal
transducer and activator of transcription (STAT) family, Stat1α, Stat3, and Stat5, in the human …
transducer and activator of transcription (STAT) family, Stat1α, Stat3, and Stat5, in the human …
In vitro development of erythroid and megakaryocytic cells from a UT-7 subline, UT-7/GM
UT-7 is a human megakaryoblastic leukemia cell line with absolute dependence on
interleukin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), or erythropoietin …
interleukin-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), or erythropoietin …
Induced megakaryocytic maturation of the human leukemia cell line UT-7 results in down-modulation of erythropoietin receptor gene expression
N Komatsu, H Fujita - Cancer research, 1993 - AACR
Erythropoietin (Epo) affects not only erythrocyte production but, in vitro, also promotes
megakaryocyte maturation. However, the mechanism of action of Epo on megakaryocytic …
megakaryocyte maturation. However, the mechanism of action of Epo on megakaryocytic …
Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB
AK Boer, AL Drayer, H Rui… - Blood, The Journal of the …, 2002 - ashpublications.org
Erythroid colony formation in response to erythropoietin (EPO) stimulation is enhanced by
costimulating the cells with prostaglandin-E2 (PGE2). The present study further analyzed the …
costimulating the cells with prostaglandin-E2 (PGE2). The present study further analyzed the …
Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell …
The UT-7 cell line was established from a patient with a megakaryoblastic leukemia
(Komatsu et al, Cancer Res 51: 341, 1991). Its proliferation is strictly dependent on the …
(Komatsu et al, Cancer Res 51: 341, 1991). Its proliferation is strictly dependent on the …
Constitutive activation of Stat1 and Stat3 in primary erythroleukemia cells
K Kirito, T Nagashima, K Ozawa, N Komatsu - International journal of …, 2002 - Springer
Signal transducers and activators of transcription (Stat) proteins play important roles in the
regulation of hematopoiesis as downstream molecules of cytokine signal transduction …
regulation of hematopoiesis as downstream molecules of cytokine signal transduction …
Cytokine-mediated erythroid maturation in megakaryoblastic human cell line HU-3.
DA Morgan, R Class, G Soslau… - Experimental hematology, 1997 - europepmc.org
HU-3 is a bipotential cell line derived from the bone marrow of a patient with
megakaryoblastic leukemia. Continuously proliferating cells evolved from cultures …
megakaryoblastic leukemia. Continuously proliferating cells evolved from cultures …
Inhibition of the erythropoietin-induced erythroid differentiation by granulocyte-macrophage colony-stimulating factor in the human UT-7 cell line is not due to a …
The human pluripotent UT-7 cell line is growth factor-dependent for proliferation and
differentiation. We have previously shown that (1) granulocyte-macrophage colony …
differentiation. We have previously shown that (1) granulocyte-macrophage colony …
Granulocyte-macrophage colony-stimulating factor-dependent growth and erythropoietin-induced differentiation of a human cell line MB-02
DA Morgan, DL Gumucio, I Brodsky - 1991 - ashpublications.org
Peripheral blood blasts from a patient with acute megakaryoblastic leukemia were placed
into liquid cultures with recombinant growth factors. Growth, but not differentiation, was …
into liquid cultures with recombinant growth factors. Growth, but not differentiation, was …