Breakdown of the extracellular matrix (ECM) is accomplished by the concerted action of
several proteases, including the urokinase plasminogen-activator (uPA) system and matrix …

The urinary-type plasminogen activator, or uPA, controls matrix degradation through the
conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin …

The plasminogen activator (PA) system is an extracellular proteolytic enzyme system
associated with various physiological and pathophysiological processes. A large body of …

Abstract Background Urokinase-type Plasminogen Activator (uPA), a serine protease, plays
a pivotal role in human breast cancer metastasis by mediating the degradation of …

Cancer dissemination and metastasis is synonymous with invasive cell migration; a process
in which the extracellular matrix (ECM) plays the dual role of the substratum on which the …

Background: Urokinase (uPA) and the urokinase receptor (uPAR) form a multifunctional
system capable of concurrently regulating pericellular proteolysis, cell-surface adhesion …

Urokinase plasminogen activator (uPA) system regulates extracellular matrix remodelling by
activating ubiquitous protease plasmin in many important physiological processes. The …

The plasminogen/plasmin system, urokinase-type plasminogen activator (uPA), its receptor
(uPAR), and its inhibitor (PAI-1), influence extracellular proteolysis and cell migration in lung …

Tumor proteases and inhibitors have been associated with paradoxical effects on tumor
progression in preclinical and clinical settings. We previously reported that urokinase (uPA) …

The urokinase plasminogen activator system is a family of serine proteases which consists
of uPA (urokinase plasminogen activator), uPAR (urokinase type plasminogen activator …