Nearly 70 years ago, Haaland [1] recognised successive stages in the development of
mammary and lung tumors, and leukemia in mice. He stressed the biological significance of …

Liver cell cancer can be induced in animals by a diverse group of chemicals. The majority of
these require metabolic conversion to a reactive derivative in order to initiate …

In the study of neoplastic changes by biochemi cal as distinct from histochemical methods,
the use of liver has obvious advantages— notably the predominance of one type of cell …

Benign and malignant tumors are composed of neoplastic cells which by definition have lost
their proliferation control, ie multiply in the absence of any physiologic need for more cells …

Publisher Summary This chapter reviews the sequence of cellular and other changes during
cancer development in selected sites in experimental animals and in humans. It highlights …

It has been known for many years that a latent period exists between the administration of a
carcinogen to an organism and the actual appearance of pathologically or clinically …

We can follow in culture the spontaneous neoplastic transformation of one epithelial cell
strain derived from normal rat liver and determine, by comparison with other liver cell strains …

The objective of this study was to compare the fine structure of presumptive preneoplastic
hepatocytes at various times during liver carcinogenesis with that of normal, developing, and …

In a pioneering study on experimental hepatocarcinogenesis, Sasaki and Yoshida [1]
detailed the step by step changes of the liver parenchyma leading to the development of …

The sequence of possible cellular, tissue, biochemical, and molecular changes that are
important during the development of experimental liver cancer with chemicals is reviewed …