Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis

MV Maddali, M Churpek, T Pham… - The lancet respiratory …, 2022 - thelancet.com
Background Two acute respiratory distress syndrome (ARDS) subphenotypes
(hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and …

The acute respiratory distress syndrome

MA Matthay, LB Ware… - The Journal of clinical …, 2012 - Am Soc Clin Investig
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can …

Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies

CS Calfee, DR Janz, GR Bernard, AK May… - Chest, 2015 - Elsevier
BACKGROUND ARDS is a heterogeneous syndrome that encompasses lung injury from
both direct and indirect sources. Direct ARDS (pneumonia, aspiration) has been …

Mechanisms of acute lung injury/acute respiratory distress syndrome

BT Suratt, PE Parsons - Clinics in chest medicine, 2006 - chestmed.theclinics.com
In the 4 decades that have elapsed since Ashbaugh and colleagues [1] first described acute
lung injury/acute respiratory distress syndrome (ALI/ARDS), tremendous strides have been …

Pathophysiology of acute lung injury and the acute respiratory distress syndrome

LB Ware - Seminars in respiratory and critical care medicine, 2006 - thieme-connect.com
Since the adult respiratory distress syndrome was first described substantial progress has
been made in understanding the pathogenesis of this complex syndrome. This review …

Emerging drugs for treating the acute respiratory distress syndrome

TD Shaw, DF McAuley, CM O'Kane - Expert opinion on emerging …, 2019 - Taylor & Francis
Introduction: The acute respiratory distress syndrome (ARDS) is a common and catastrophic
condition, with a high mortality rate and economic burden on society. Despite 50 years of …

Genetic polymorphisms associated with susceptibility and outcome in ARDS

RP Marshall, S Webb, MR Hill, SE Humphries… - Chest, 2002 - journal.chestnet.org
68S Thomas L. Petty 44th Annual Aspen Lung Conference: Pulmonary Genetics, Genomics,
Gene Therapy be associated with a lower mortality rate in patients with acute respiratory …

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial

CS Calfee, KL Delucchi, P Sinha… - The Lancet …, 2018 - thelancet.com
Background Precision medicine approaches that target patients on the basis of disease
subtype have transformed treatment approaches to cancer, asthma, and other …

Epidemiology of acute lung injury and acute respiratory distress syndrome

F Frutos-Vivar, N Nin, A Esteban - Current opinion in critical care, 2004 - journals.lww.com
The epidemiology of ALI and ARDS has some issues to improve, such as the accuracy of the
clinical criteria of ALI/ARDS. Future research must to include study of genetic polymorphisms …

Treatment of ARDS

RG Brower, LB Ware, Y Berthiaume, MA Matthay - Chest, 2001 - Elsevier
Improved understanding of the pathogenesis of acute lung injury (ALI)/ARDS has led to
important advances in the treatment of ALI/ARDS, particularly in the area of ventilator …