Genome‐wide association (GWA) can elucidate molecular genetic bases for human
individual differences in complex phenotypes that include vulnerability to addiction. Here …

Background Vulnerabilities to dependence on addictive substances are substantially
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Family, adoption and twin data each support substantial heritability for addictions. Most of
this heritable influence is not substance-specific. The overlapping genetic vulnerability for …

Substantial genetic contributions to addiction vulnerability are supported by data from twin
studies, linkage studies, candidate gene association studies and, more recently, Genome …

Association genome scanning is of increasing interest for identifying the chromosomal
regions that contain gene variants that contribute to vulnerability to complex disorders …

Abundant evidence from family, adoption, and twin studies point to large genetic
contributions to individual differences in vulnerability to develop dependence on one or …

Classical genetic studies document strong complex genetic contributions to abuse of
multiple addictive substances. These genetic influences are more prominent in the later …

Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

Background Classical genetic studies provide strong evidence for heritable contributions to
susceptibility to developing dependence on addictive substances. Candidate gene and …