An important goal in protein engineering is to control associations between designed
proteins. This is most often done by fusing known, naturally occurring oligomerization …

Many proteins assemble as oligomeric complexes and in several cases a distinct domain
mediates the interaction between the subunits. The identification of new oligomerization …

For decades proteins were thought to interact in a “lock and key” system, which led to the
definition of a paradigm linking stable three-dimensional structure to biological function. As a …

Once the sequence of a genome is in hand, understanding the function of its encoded
proteins becomes a task of paramount importance. Much like the biochemists who first …

A large fraction of cellular proteins are oligomeric. Protein oligomerization may often be an
advantageous feature from the perspective of protein evolution and has probably evolved by …

Although there are a wide variety of methods available to study protein–protein interactions
using biochemical approaches, the yeast two-hybrid system (Fields and Song 1989) has …

Background Recent sequencing projects and the growth of sequence data banks enable
oligopeptide patterns to be characterized on a genome or kingdom level. Several studies …

We scanned the Swissprot databank to study the distribution of oligopeptides in sequenced
proteins. We observed that in 7839000 amino acids in the bank, the frequency is strongly …

Cellular functions of proteins are strongly influenced by their interactions with other proteins.
The frequency of protein interactions is a function of the local concentration of two proteins …

Despite their seemingly endless diversity, proteins adopt a limited number of structural
forms. It has been estimated that 80% of proteins will be found to adopt one of only about …