Aims/hypothesis Upregulation of the reactive oxygen species (ROS)-producing enzyme
NADPH oxidase (NOX)-1 in islets and beta cells follows acute exposure to inflammatory …

It has been proposed that pancreatic beta-cell dysfunction in type 2 diabetes is promoted by
oxidative stress caused by NADPH oxidase (Nox) over-activity. The aim of the present study …

Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells
and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell …

Predictions of diabetes prevalence over the next decades warrant the aggressive discovery
of new approaches to stop or reverse loss of functional beta cell mass. Beta cells are …

NADPH oxidase-1 (NOX-1) is upregulated in beta cells in response to pro-inflammatory
cytokines. Inhibition of NADPH oxidase activity blocked stimulated NOX-1 expression (p< …

OBJECTIVE The role of NOX2-containing NADPH oxidase in the development of diabetes is
not fully understood. We hypothesized that NOX2 deficiency decreases reactive oxygen …

In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …

Aims/hypothesis The activation of NADPH oxidase has been implicated in NEFA-induced
beta cell dysfunction. However, the causal role of this activation in vivo remains unclear …

Objective By exposing mice carrying a deletion of NADPH oxidase isoform 4, NOX4,
specifically in pancreatic β cells (βNOX4−/−) to nutrient excess stimulated by a high‐fat diet …

AIMS: NADPH oxidase (NOX) is a known source of superoxide anions in phagocytic and
non-phagocytic cells. In this study, the presence of this enzyme in human pancreatic islets …