Since the beginning of the SARS-CoV-2 pandemic, COVID-19 appeared as a unique
disease with unconventional tissue and systemic immune features. Here we show a COVID …

The mechanisms underlying the immune remodeling and severity response in coronavirus
disease 2019 (COVID-19) are yet to be fully elucidated. Our comprehensive integrative …

Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …

Summary Coronavirus disease 2019 (COVID-19) manifests with a range of severities, but
immune signatures of mild and severe disease are still not fully understood. Here, we use …

Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …

Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …

Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

Summary The coronavirus disease 2019 (COVID-19) pandemic poses a current world-wide
public health threat. However, little is known about its hallmarks compared to other infectious …

Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …