[HTML][HTML] Knockdown of CUL4B suppresses the proliferation and invasion in non-small cell lung cancer cells
X Wang, Z Chen - Oncology Research, 2016 - ncbi.nlm.nih.gov
Abstract Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase
complexes, was found to be overexpressed in many types of tumors. However, the …
complexes, was found to be overexpressed in many types of tumors. However, the …
Cullin 3 overexpression inhibits lung cancer metastasis and is associated with survival of lung adenocarcinoma
J Zhou, S Zhang, Y Xu, W Ye, Z Li, Z Chen… - Clinical & Experimental …, 2020 - Springer
Abstract Cullin 3 (CUL3), a molecular scaffold of Cullin-RING ubiquitin ligase, plays an
important role in regulating biological processes through modulating the ubiquitylation and …
important role in regulating biological processes through modulating the ubiquitylation and …
[HTML][HTML] CUL4B promotes aggressive phenotypes of HNSCC via the activation of the Wnt/β‐catenin signaling pathway
Y Wang, D Yue - Cancer medicine, 2019 - ncbi.nlm.nih.gov
Previous studies have revealed that CUL4B is overexpressed in various types of cancer and
that its overexpression is related to the progression and metastasis of tumors. However, the …
that its overexpression is related to the progression and metastasis of tumors. However, the …
[HTML][HTML] Cul4A modulates invasion and metastasis of lung cancer through regulation of ANXA10
MS Hung, YC Chen, PY Lin, YC Li, CC Hsu, JH Lung… - Cancers, 2019 - mdpi.com
Cullin 4A (Cul4A) is overexpressed in a number of cancers and has been established as an
oncogene. This study aimed to elucidate the role of Cul4A in lung cancer invasion and …
oncogene. This study aimed to elucidate the role of Cul4A in lung cancer invasion and …
[HTML][HTML] CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR
Y Wang, P Zhang, Z Liu, Q Wang, M Wen, Y Wang… - Molecular cancer, 2014 - Springer
Background CUL4A has been proposed as oncogene in several types of human cancer, but
its clinical significance and functional role in human non-small cell lung cancer (NSCLC) …
its clinical significance and functional role in human non-small cell lung cancer (NSCLC) …
Dysregulation of the miR‐194–CUL 4B negative feedback loop drives tumorigenesis in non‐small‐cell lung carcinoma
J Mi, Y Zou, X Lin, J Lu, X Liu, H Zhao, X Ye… - Molecular …, 2017 - Wiley Online Library
Cullin 4B (CUL 4B), a scaffold protein that assembles CRL 4B ubiquitin ligase complexes, is
overexpressed in many types of cancers and represses many tumor suppressors through …
overexpressed in many types of cancers and represses many tumor suppressors through …
[HTML][HTML] Dysregulation of CUL4A and CUL4B ubiquitin ligases in lung cancer
The Cullin-RING ubiquitin ligase 4 (CRL4) is implicated in controlling cell cycle, DNA
damage repair, and checkpoint response based on studies employing cell lines and mouse …
damage repair, and checkpoint response based on studies employing cell lines and mouse …
Lung tumourigenesis in a conditional Cul4A transgenic mouse model
YL Yang, MS Hung, Y Wang, J Ni, JH Mao… - The Journal of …, 2014 - Wiley Online Library
Abstract Cullin4A (Cul4A) is a scaffold protein that assembles cullin–RING ubiquitin ligase
(E3) complexes and regulates many cellular events, including cell survival, development …
(E3) complexes and regulates many cellular events, including cell survival, development …
Cullin-4B promotes cell proliferation and invasion through inactivation of p53 signaling pathway in colorectal cancer
M Zhong, L Zhou, J Zou, Y He, Z Fang… - Pathology-Research and …, 2021 - Elsevier
Abstract Cullin 4B (CUL4B) is a member of the Cullin RING E3 ligase family, which is found
to be overexpressed in multiple cancers, thus facilitating tumorigenesis and progression …
to be overexpressed in multiple cancers, thus facilitating tumorigenesis and progression …
CUL4B promotes aggressive phenotypes of renal cell carcinoma via upregulating c-met expression
S Chen, Y Wang, L Chen, Y Xia, J Cui, W Wang… - … International Journal of …, 2021 - Elsevier
Abstract Cullin 4B (CUL4B), encoding a scaffold protein in Cullin RING ubiquitin-ligase
complexes (CRL4B), is overexpressed and serves as an oncogene in various solid tumors …
complexes (CRL4B), is overexpressed and serves as an oncogene in various solid tumors …