A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

The initial phases of embryonic development occur in the absence of de novo transcription
and are instead controlled by maternally inherited mRNAs and proteins. During this initial …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

DNA methylation, chromatin states and their interrelationships represent critical epigenetic
information, but these are largely unknown in human early embryos. Here, we apply single …

BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …

Chromatin structure is intimately connected with gene expression and cell identity. Here we
review recent advances in the field and discuss how establishment of cell identity during …

In mammals, all somatic development originates from lineage segregation in early embryos.
However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell …

Extensive epigenetic reprogramming occurs during preimplantation embryo development.
However, it remains largely unclear how the drastic epigenetic reprogramming contributes to …