[HTML][HTML] Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food

LE Linders, L Patrikiou, M Soiza-Reilly… - Nature …, 2022 - nature.com
Stress can cause overconsumption of palatable high caloric food. Despite the important role
of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms …

An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes

J Cai, Y Jiang, Y Xu, Z Jiang, C Young, H Li… - Neuron, 2024 - cell.com
Maladaptation in balancing internal energy needs and external threat cues may result in
eating disorders. However, brain mechanisms underlying such maladaptations remain …

Diet-induced inflammation in the anterior paraventricular thalamus induces compulsive sucrose-seeking

J Cheng, X Ma, C Li, R Ullah, X Wang, J Long… - Nature …, 2022 - nature.com
Overconsumption of palatable food may initiate neuroadaptive responses in brain reward
circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) …

Identification of a stress-sensitive anorexigenic neurocircuit from medial prefrontal cortex to lateral hypothalamus

RE Clarke, K Voigt, A Reichenbach, R Stark… - Biological …, 2023 - Elsevier
Background A greater understanding of how the brain controls appetite is fundamental to
developing new approaches for treating diseases characterized by dysfunctional feeding …

[HTML][HTML] Depression of accumbal to lateral hypothalamic synapses gates overeating

S Thoeni, M Loureiro, EC O'Connor, C Lüscher - Neuron, 2020 - cell.com
Overeating typically follows periods of energy deficit, but it is also sustained by highly
palatable foods, even without metabolic demand. Dopamine D1 receptor-expressing …

[HTML][HTML] Parallels and overlap: the integration of homeostatic signals by mesolimbic dopamine neurons

TM Hsu, JE McCutcheon, MF Roitman - Frontiers in psychiatry, 2018 - frontiersin.org
Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed,
animals and humans have fundamental drives to procure (appetitive behaviors) and …

[HTML][HTML] Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding

DJ Christoffel, JJ Walsh, BD Heifets, P Hoerbelt… - Nature …, 2021 - nature.com
Hedonic feeding is driven by the “pleasure” derived from consuming palatable food and
occurs in the absence of metabolic need. It plays a critical role in the excessive feeding that …

Stress integration by an ascending adrenergic-melanocortin circuit

C Laule, N Sayar-Atasoy, I Aklan, H Kim… - …, 2024 - nature.com
Stress is thought to be an important contributing factor for eating disorders; however, neural
substrates underlying the complex relationship between stress and appetite are not fully …

Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids

G Labouèbe, S Liu, C Dias, H Zou, JCY Wong… - Nature …, 2013 - nature.com
The prevalence of obesity has markedly increased over the past few decades. Exploration of
how hunger and satiety signals influence the reward system can help us understand non …

Feelings about food: the ventral tegmental area in food reward and emotional eating

FJ Meye, RAH Adan - Trends in pharmacological sciences, 2014 - cell.com
Overconsumption of high caloric food plays an important role in the etiology of obesity.
Several factors drive such hedonic feeding. High caloric food is often palatable. In addition …