Two tetrahedral nickel (II) cages,[Ni4L6] 8+(1 and 2), with large rigid aromatic ligands were
synthesized, and their G‐quadruplex DNA binding abilities were investigated. The crystal …

DNA is considered an important target for drug design and development. Until recently, the
focus was on double-stranded (duplex) DNA structures. However, it has now been shown …

Since potential therapeutic significance had been discovered for quadruplex secondary
structures of nucleic acids, many compounds stabilizing these targets were identified. The …

There is currently significant interest in the development of G‐quadruplex‐interactive
compounds, given the relationship between the ability to stabilize these non‐canonical DNA …

The growing interest in G-quadruplex (G4) structure and function is motivating intense efforts
to develop G4-binding ligands. This chapter describes the design and testing of peptide …

An unprecedented strategy to control the quadruplex-vs duplex-DNA selectivity of a ligand is
reported. We designed a compound whose structure can rearrange when it interacts with a …

(Figure Presented) A new G-quadruplex binding ligand, namely 1H-pyrazole-3-carboxy-4-
methyl-5-phenyl-(1H-indol-3-ylmethylene) hydrazide, was identified from a database of 100 …

G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …

G-quadruplex structures formed by oligodeoxyribonucleotides TGGUNH2GGT (AM, UNH2=
5-amino-2′-deoxyuridine), TGGUBrGGT (BR, UBr= 5-bromo-2′-deoxyuridine) and …

A series of novel 2, 4, 6-triarylpyridines have been synthesized and their interactions with
intramolecular G-quadruplexes have been measured by Förster Resonance Energy …