Background: Ischemic stroke is the third leading cause of death and the most frequent cause
of permanent disability in adults worldwide. Tremendous advances have been made in …

Osteopontin (OPN) is a multifunctional protein which has shown neuroprotective properties
in animal models of cerebral ischemia. Nevertheless, its role in acute human stroke has not …

Acute brain injury is the leading cause of human death and disability worldwide, which
includes intracerebral haemorrhage, subarachnoid haemorrhage, cerebral ischaemia …

Rupture of intracranial aneurysms causes subarachnoid hemorrhage (SAH), of which the
treatment remains the most difficult among cerebrovascular disorders even in this modern …

Osteopontin (OPN) is a secreted extracellular phosphoprotein involved in diverse biologic
functions, including inflammation, cell migration, and antiapoptotic processes. Here we …

Background After an acute ischaemic stroke (AIS), several inflammatory biomarkers have
been investigated, but their predictive role on functional recovery remains to be validated …

Osteopontin (OPN) was shown to be involved in inflammatory and degenerative processes
of the nervous system. In multiple sclerosis, the role of OPN has been studied in the …

Brain trauma induces a multitude of reactions at molecular, cellular, and tissue levels, some
of which are beneficial to recovery, whereas others are detrimental. Osteopontin (OPN), a …

Osteopontin (OPN) is a pleiotropic protein implicated in various inflammatory responses
including ischemia-reperfusion (IR) injury. Two distinct forms of the protein have been …

Osteopontin (OPN) is a phosphorylated glycoprotein possessing an arginine-glycine-
aspartate (RGD)-motif, which binds to several cell surface integrins and mediates a wide …