Lysis of tumor cells by CD3+ 4-8-16+ T cell receptor alpha beta-clones, regulated via CD3 and CD16 activation sites, recombinant interleukin 2, and interferon beta 1.
RJ Van de Griend, WJ Tax… - … (Baltimore, Md.: 1950 …, 1987 - journals.aai.org
Abstract A small subpopulation (about 2%) of normal CD3+ human T lymphocytes lacks both
CD4 and CD8 antigens. We have cloned these cells from peripheral blood lymphocytes …
CD4 and CD8 antigens. We have cloned these cells from peripheral blood lymphocytes …
Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens.
LL Lanier, JJ Ruitenberg, JH Phillips - The Journal of experimental …, 1986 - rupress.org
CD3+ T lymphocytes expressing neither CD4 nor CD8 antigens exist in normal human
peripheral blood in low frequency (approximately 3% of lymphocytes). The CD3+, 4-, 8 …
peripheral blood in low frequency (approximately 3% of lymphocytes). The CD3+, 4-, 8 …
Induction of lysis by T cell receptor gamma delta+/CD3+ T lymphocytes via CD2 requires triggering via the T11. 1 epitope only.
PS Goedegebuure, DM Segal, E Braakman… - … (Baltimore, Md.: 1950 …, 1989 - journals.aai.org
The requirements for activation of the lytic machinery through CD2 of TCR gamma
delta+/CD3+ cells were examined, by utilizing bispecific heteroconjugates containing anti …
delta+/CD3+ cells were examined, by utilizing bispecific heteroconjugates containing anti …
Clonal analysis of CD4 CD8‐human thymocytes expressing a T cell receptor γ/δ chain. Direct evidence for the de novo expression of CD8 surface antigen and of …
MC Mingari, P Varese, C Bottino… - European journal of …, 1988 - Wiley Online Library
Abstract CD4− CD8− human thymocytes were obtained by treating total thymocyte
suspensions with antiCD4 and anti‐CD8 monoclonal antibodies (mAb) and complement …
suspensions with antiCD4 and anti‐CD8 monoclonal antibodies (mAb) and complement …
Activation of human cytolytic cells through CD2/T11. Comparison of the requirements for the induction and direction of lysis of tumor targets by T cells and NK cells.
CF Scott Jr, S Bolender, GD McIntyre… - … (Baltimore, Md.: 1950 …, 1989 - journals.aai.org
We studied the mechanisms whereby human T cells and NK cells are activated and directed
to lyse tumor targets through the CD2 (T11/E-rosette) Ag. Using two cloned NK lines, we …
to lyse tumor targets through the CD2 (T11/E-rosette) Ag. Using two cloned NK lines, we …
CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene.
The expression of genes encoding different polypeptide chains of the TCR-CD3 complex
was analyzed in a panel of cloned MHC-unrestricted cytotoxic cells. The clones were …
was analyzed in a panel of cloned MHC-unrestricted cytotoxic cells. The clones were …
Definition of a population of CD4-8-T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4.
M Londei, A Verhoef, P De Berardinis… - Proceedings of the …, 1989 - National Acad Sciences
Whereas most T cells express surface CD4 or CD8 molecules, a minority lacks both. CD4-8-
cells usually express the gamma delta T-cell receptor, but here we describe a population of …
cells usually express the gamma delta T-cell receptor, but here we describe a population of …
Double-negative (CD4-CD8-) T cells with an alpha/beta T cell receptor. Non-MHC-restricted cytolytic activity and lymphokine production.
EG Brooks, DP Wirt, RM Goldblum… - … (Baltimore, Md.: 1950 …, 1990 - journals.aai.org
T cell lines with a novel phenotype (CD3+ TCR-alpha/beta+ CD4-CD8-) were developed
from the peripheral blood of a patient with a combined immunodeficiency and tissue injury …
from the peripheral blood of a patient with a combined immunodeficiency and tissue injury …
A novel population of expanded human CD3+ CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency.
PH Lu, RS Negrin - Journal of immunology (Baltimore, Md.: 1950), 1994 - journals.aai.org
Recently, we have reported a novel protocol for the generation of highly efficient cytotoxic
effector cells by culturing PBLs in the presence of IFN-gamma, IL-2, mAb against CD3, and …
effector cells by culturing PBLs in the presence of IFN-gamma, IL-2, mAb against CD3, and …
Analysis of the functional capabilities of CD3+ CD4-CD8-and CD3+ CD4+ CD8+ human T cell clones.
SS Patel, MC Wacholtz, AD Duby… - … (Baltimore, Md.: 1950 …, 1989 - journals.aai.org
The functional capabilities of human peripheral blood CD3+ CD4-CD8-and CD3+ CD4+
CD8+ T cell clones were examined. The clones were generated by culturing purified …
CD8+ T cell clones were examined. The clones were generated by culturing purified …