The pharmacokinetics of colchicine were studied in six healthy male and four elderly female
volunteers after iv and oral administration. Plasma samples were collected over 72 h and …

In a randomized 2-way cross-over study with twelve healthy male volunteers, two colchicine
preparations (tablets, A vs. oral solution, B) were tested. The preparations were …

Colchicine is an antimitotic drug used to treat gout and familial Mediterranean fever.
Absolute bioavailability, pharmacokinetics, and absorption characteristics of colchicine after …

The pharmacokinetics of colchicine has been studied in nine healthy male volunteers after
oral doses of 0.5, 1, and 1.5 mg as tablets. Plasma and urine samples were collected over …

1 A specific and sensitive radioimmunoassay was used to study the toxicokinetics of
colchicine in seven cases of acute human poisoning. Post-mortem tissue concentrations of …

Colchicine is a tricyclic, lipid-soluble alkaloid derived from the plant of the Lily family
Colchicum autumnale, sometimes called the “autumn crocus”. It is predominantly …

Plasma colchicine levels have been measured serially after the oral administration of 1.0 mg
of the drug to ten volunteer subjects. Peak colchicine concentrations averaged 0.323±0.173 …

Inasmuch as leukocytes were reported to be an active pharmacologic compartment,
colchicine disposition was determined in plasma, granulocytes, and mononuclear cells in …

Abstract Background and Objective The effect of renal impairment on colchicine
pharmacokinetics in patients with chronic kidney disease (CKD) has not been studied …

A rapid and sensitive method to determine colchicine in human plasma by liquid
chromatography–tandem mass spectrometry (LC–MS/MS) has been developed. Colchicine …