We investigated the association between haplotypes of fibrinogen alpha (FGA), beta (FGB),
and gamma (FGG), total fibrinogen levels, fibrinogen γ′(γA/γ′ plus γ′/γ′) levels, and risk …

As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …

Fibrin fibers form the structural backbone of blood clots; fibrinolysis is the process in which
plasmin digests fibrin fibers, effectively regulating the size and duration of a clot. To …

When blood vessel walls are injured by mechanical forces or due to the atherosclerotic
plaques, platelets are activated and adhere to these injured sites, and form platelet …

Elevated plasma clot lysis time (CLT) increases risk of venous and arterial thrombosis. It is
unclear which fibrinolytic factors contribute to thrombosis risk. In 743 healthy control subjects …

The spontaneous lysis of a coronary thrombus is a natural protective mechanism against
lasting occlusion and downstream infarction. Thrombus stability is thus a direct determinant …

Background Polymorphisms in the fibrinogen and factor XIII genes are associated with
atherothrombotic risk, but clinical studies have produced inconsistent results and laboratory …

Essentials• Patients with cirrhosis have hemostatic changes, which may contribute to a risk
of thrombosis.• This in vitro study compares clot formation and structure between patients …

Atherothrombosis is a leading cause of cardiovascular mortality and long-term morbidity.
Platelets and coagulation proteases, interacting with circulating cells and in different …