The pathophysiology of depression is heavily dependent on inflammation. Evidence
suggests that the etiology of depression is linked with NLRP3 inflammasome-induced …

Esculetin is one of the major bioactive compounds of Cichorium intybus L. The main
purpose of the present study was to investigate the effects and possible underlying …

Depression is a serious mental illness, mainly characterized as large mood swings and
sleep, diet, and cognitive function disorders. NLPR3, one of the inflammasomes that can be …

Background: Depression is a common and potentially life-threatening mental illness, and
currently, there is a lack of effective treatment. It has been reported that dehydrocorydaline …

Background: Emerging evidence indicates that NLRP3 inflammasome-induced inflammation
plays a crucial role in the pathogenesis of depression. Thus, inhibition of NLRP3 …

Depression is a common but serious mental illness; meanwhile, it is also an inflammatory
disorder. Toll-like receptor 4 (TLR4), as the pattern recognition receptor, has been shown to …

Background and objective Endoplasmic reticulum stress (ERS), as a primary defense
mechanism against stress, is closely related to mental disorders, but its pathogenesis is still …

There is increasing evidence showing that inflammation is associated with depression in
humans. Hesperidin, a natural bioflavonoid, has performed excellent effects on depression …

Background: Depression has recently been referred to as a neuroimmune disease because
it is characterized by inflammatory changes in the cerebral cortex and hippocampus. Studies …

Inflammation and oxidative stress are involved in the pathophysiology of anxiety and
depression. Esculetin (ESC), a coumarin derived potent antioxidant, also possessing anti …