Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Age is the main risk factor for the onset of neurodegenerative diseases. A decline of
mitochondrial function has been observed in several age-dependent neurodegenerative …

Mitochondria are essential for ensuring numerous fundamental physiological processes
such as cellular energy, redox balance, modulation of Ca2+ signaling and important …

Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to
modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen …

Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

Mitochondria are responsible for the majority of energy production in energy-intensive
tissues like brain, modulate Ca+ 2 signaling and control initiation of cell death. Because of …

Calcium (Ca2+) is a versatile secondary messenger involved in the regulation of a plethora
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …

Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

A growing body of evidence suggests the alteration of the reduction-oxidation (redox)
homeostasis in the brain grown with the increasing of the age. The brain is composed of …

Mitochondria have been increasingly recognized as the important players in the aging
process. Most aging-related diseases, particularly, neurodegenerative diseases, have …