G6PD testing and radical cure for Plasmodium vivax in Cambodia: A mixed methods implementation study

ST Kheang, R Ridley, E Ngeth, P Ir, P Ngor… - PLoS …, 2022 - journals.plos.org
Introduction Cambodia aims to eliminate malaria by 2025, however tackling Plasmodium
vivax (P. v) presents multiple challenges. The prevalence of glucose-6-phosphate …

Radical cure for Plasmodium vivax malaria after G6PD qualitative testing in four provinces in Cambodia, results from Phase I implementation

D Lek, YC Tsai, J Hirano, S Sovannaroth, V Bunreth… - Malaria Journal, 2024 - Springer
Background Cambodia aims to eliminate all forms of malaria by 2025. In 2020, 90% of all
malaria cases were Plasmodium vivax. Thus, preventing P. vivax and relapse malaria is a …

Implementation of Glucose-6-Phosphate Dehydrogenase (G6PD) testing for Plasmodium vivax case management, a mixed method study from Cambodia

SA Cassidy-Seyoum, K Chheng… - PLOS Global Public …, 2024 - journals.plos.org
Plasmodium vivax remains a challenge for malaria elimination since it forms dormant liver
stages (hypnozoites) that can reactivate after initial infection. 8-aminoquinolone drugs kill …

Implementation of G6PD testing and primaquine for P. vivax radical cure: operational perspectives from Thailand and Cambodia

S Kitchakarn, D Lek, S Thol, C Hok… - WHO South-East Asia …, 2017 - journals.lww.com
Following progressive success in reducing the burden of malaria over the past two decades,
countries of the Asia Pacific are now aiming for elimination of malaria by 2030. Plasmodium …

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

K Thriemer, B Ley, A Bobogare, L Dysoley, MS Alam… - Malaria journal, 2017 - Springer
The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest
challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the …

Linked-evidence modelling of qualitative G6PD testing to inform low- and intermediate-dose primaquine treatment for radical cure of Plasmodium vivax

ML Gatton - PLOS Neglected Tropical Diseases, 2024 - journals.plos.org
Background Radical cure of Plasmodium vivax infections is key to the control of vivax
malaria. However, the standard doses of 8-aminoquinoline drugs used for radical cure can …

Rolling out the radical cure for vivax malaria in Asia: a qualitative study among policy makers and stakeholders

B Adhikari, GR Awab, L von Seidlein - Malaria Journal, 2021 - Springer
Background Wide-spread implementation of treatment regimens for the radical cure of vivax
malaria is hindered by a range of factors. This has resulted in an increase in the relative …

Further evidence needed to change policy for the safe and effective radical cure of vivax malaria: Insights from the 2019 annual APMEN Vivax Working Group meeting

VSH Ruwanpura, S Nowak… - Asia & the Pacific …, 2021 - Wiley Online Library
New diagnostics and treatment options for the radical cure of Plasmodium vivax malaria are
now available. At the 2019 annual meeting of the Vivax Working Group of the Asia Pacific …

A review of the current status of G6PD deficiency testing to guide radical cure treatment for vivax malaria

A Sadhewa, S Cassidy-Seyoum, S Acharya, A Devine… - Pathogens, 2023 - mdpi.com
Plasmodium vivax malaria continues to cause a significant burden of disease in the Asia-
Pacific, the Horn of Africa, and the Americas. In addition to schizontocidal treatment, the 8 …

Barriers to routine G6PD testing prior to treatment with primaquine

B Ley, K Thriemer, J Jaswal, E Poirot, MS Alam… - Malaria journal, 2017 - Springer
Background Primaquine is essential for the radical cure of vivax malaria, however its broad
application is hindered by the risk of drug-induced haemolysis in individuals with glucose-6 …