Zinc is concentrated in the dorsal horn of the spinal cord and has been proposed to alter
excitability of primary afferent C-fibers, structures believed to be important in nociceptive …

Capsaicin depolarizes primary afferent C-fibers releasing substance P (SP) whose N-
terminal metabolites appear to play a role in the development of antinociception. Because …

Zinc enriched (ZEN) neurons and terminals are abundant in the rodent spinal cord. Zinc ions
have been suggested to modulate the excitability of primary afferent fibers believed to be …

Zinc has recently been shown to alleviate inflammatory hyperalgesia. In the present study,
we showed that intrathecal, intraplantar or systemic injection of zinc chloride significantly …

The effect of systemic zinc administration on the inflammatory hyperalgesia induced by
intraplantar injections of either complete Freund's adjuvant (CFA) or bacterial endotoxin …

A marked decrease in zinc concentration was observed in plasma (P< 0.001), hindpaw skin
(P< 0.01), and dorsal skin (P< 0.01) in zinc-deficient rats (rats fed a zinc-deficient diet for 3 …

Trace elements represent a group of essential metals or metaloids necessary for life, present
in minute amounts. Analgesic adjuvants can enhance the effect of other pain drugs or be …

Zinc and other cations were iontophoretically applied to neurones in the fronto parietal
cortex of urethane-anaesthetised rats and their effect on the activity of these cells was …

The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …

Zinc appears to play a role in synaptic transmission in the hippocampus. We tested the
hypothesis that zinc is similarly involved in sensory transmission by determining whether …