Background Several long‐term double‐blind placebo controlled trials have shown
prophylactic antidepressant therapy in unipolar depression. The goal of this work was to …

Despite marked increases in antidepressant drug prescriptions over the last 3 decades, the
burden and disability attributed to major depression are still on the rise. This calls into …

Objective: Continuation therapy with antidepressants is recommended for depressed
patients who have responded to initial treatment. We quantified its efficacy in preventing …

We now recognise that withdrawal symptoms from antidepressants are common, and can be
severe and long-lasting in some people. Many withdrawal symptoms overlap with symptoms …

Depression is the fourth-largest contributor to the global burden of disease, and it causes
profound suffering and extreme costs to health care systems and society. Although there …

Depression is a recurrent illness in which afflicted individuals have an increased risk for
recurrence as a function of a greater number of previous episodes. Consequently …

Introduction: Despite the recommendation that antidepressant treatment should be
continued for several months to reduce the risk of relapse/recurrence of depression, early …

Background Antidepressant drugs can promote remission from acute depressive episodes.
Our aim was to establish how long such treatments should be continued to prevent relapse …

The aim of this article is to discuss the validity of relapse prevention trials and the issue of
withdrawal confounding in these trials. Recommendations for long-term antidepressant …

Antidepressants are used for long periods of time and until recently there were no formal
requirements for establishing efficacy in the maintenance phase or the prophylactic phase of …