Chronic activation of neurokinin-1 receptor induces pulmonary hypertension in rats

LW Chen, CF Chen, YL Lai - American Journal of …, 1999 - journals.physiology.org
In this study we explored the hypothesis that chronic activation of neurokinin-1 (NK-1)
receptor induces pulmonary hypertension in Wistar rats. First, the activation of NK-1 receptor …

Pharmacological examination of the neurokinin-1 receptor mediating relaxation of human intralobar pulmonary artery

KE Pedersen, CK Buckner, SN Meeker… - Journal of Pharmacology …, 2000 - ASPET
The effect of selective tachykinin receptor agonists and antagonists on human isolated
intralobar pulmonary arterial rings was investigated. Neither Substance P (SP) nor …

Neurokinins induce relaxation of human pulmonary vessels through stimulation of endothelial NK1 receptors

H Mechiche, A Koroglu, L Candenas… - Journal of …, 2003 - journals.lww.com
The effects of neurokinins and neurokinin receptor selective agonists have been
investigated on human intralobar pulmonary vessels. Substance P (SP) and [Sar 9 Met (O 2) …

Temporal increase in the reactivity of pulmonary vasculature to substance P in chronically hypoxic rats

YL Lai, SJ Chu, MC Ma… - American Journal of …, 2002 - journals.physiology.org
We previously demonstrated that the pulmonary vascular response to substance P (SP)
increased in chronically hypoxic rats. This study explored the temporal increase in reactivity …

Hypoxia upregulates lung microvascular neurokinin-1 receptor expression

ED Zee, S Schomberg… - American Journal of …, 2006 - journals.physiology.org
Subacute exposure to moderate hypoxia can promote pulmonary edema formation. The
tachykinins, a family of proinflammatory neuropeptides, have been implicated in the …

The role of vagal pathway and NK1 and NK2 receptors in cardiovascular and respiratory effects of neurokinin A

K Kaczyńska, M Jampolska… - Clinical and …, 2016 - Wiley Online Library
Neurokinin A (NKA) is a peptide neurotransmitter that participates in the regulation of
breathing and the cardiovascular system. The purpose of the current study was to determine …

Bronchoconstrictor effect of the tachykinin NK3-receptor agonists [MePhe7]-neurokinin B and senktide in the isolated guinea pig lung

MR Corboz, MA Rivelli, SP Eckel - Experimental Lung Research, 2010 - Taylor & Francis
To determine whether bronchoconstriction can be mediated via the tachykinin NK3
receptors, isolated guinea pig lungs were challenged with the exogenous tachykinin NK3 …

Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.

J Solway, BM Kao, JE Jordan, B Gitter… - The Journal of …, 1993 - Am Soc Clin Investig
We tested the hypothesis that hyperpnea-induced bronchoconstriction (HIB) and hyperpnea-
induced bronchovascular hyperpermeability (HIBVH) are mediated through stimulation of …

Bronchoconstrictor and respiratory effects of neurokinin A in dogs

JE Sherwood, PJ Mauser, RW Chapman - Journal of Pharmacology and …, 1997 - ASPET
Neurokinin A (NKA) is the primary bronchoconstrictor tachykinin in the lungs of several
species, including humans and has been implicated as an important mediator of …

Neurokinin B induces oedema formation in mouse lung via tachykinin receptor‐independent mechanisms

AD Grant, R Akhtar, NP Gerard… - The Journal of …, 2002 - Wiley Online Library
The tachykinin neurokinin B (NKB) has been implicated in the hypertension that
characterises pre‐eclampsia, a condition where tissue oedema is also observed. The ability …