In this study we explored the hypothesis that chronic activation of neurokinin-1 (NK-1)
receptor induces pulmonary hypertension in Wistar rats. First, the activation of NK-1 receptor …

The effect of selective tachykinin receptor agonists and antagonists on human isolated
intralobar pulmonary arterial rings was investigated. Neither Substance P (SP) nor …

The effects of neurokinins and neurokinin receptor selective agonists have been
investigated on human intralobar pulmonary vessels. Substance P (SP) and [Sar 9 Met (O 2) …

We previously demonstrated that the pulmonary vascular response to substance P (SP)
increased in chronically hypoxic rats. This study explored the temporal increase in reactivity …

Subacute exposure to moderate hypoxia can promote pulmonary edema formation. The
tachykinins, a family of proinflammatory neuropeptides, have been implicated in the …

Neurokinin A (NKA) is a peptide neurotransmitter that participates in the regulation of
breathing and the cardiovascular system. The purpose of the current study was to determine …

To determine whether bronchoconstriction can be mediated via the tachykinin NK3
receptors, isolated guinea pig lungs were challenged with the exogenous tachykinin NK3 …

We tested the hypothesis that hyperpnea-induced bronchoconstriction (HIB) and hyperpnea-
induced bronchovascular hyperpermeability (HIBVH) are mediated through stimulation of …

Neurokinin A (NKA) is the primary bronchoconstrictor tachykinin in the lungs of several
species, including humans and has been implicated as an important mediator of …

The tachykinin neurokinin B (NKB) has been implicated in the hypertension that
characterises pre‐eclampsia, a condition where tissue oedema is also observed. The ability …