Objectives To evaluate intrathecal immunoglobulin M (IgM) production, as compared to
previously established risk factors, as risk factor for conversion from clinically isolated …

Markers predicting the course of patients with clinically isolated syndrome (CIS) toward
multiple sclerosis (MS) are urgently needed. We evaluated the predictive values of …

Background: Previous studies have demonstrated that intrathecal synthesis of IgM is
observed in multiple sclerosis (MS) and correlates with a worse disease course. These …

Objective To determine the best method to measure intrathecal immunoglobulin (Ig) M
synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared …

One of the great challenges related to multiple sclerosis (MS) research is the identification of
markers of prognosis and treatment response. In the last couple of decades, an association …

Background: The intrathecal production of immunoglobulin (Ig) is a major biological feature
of multiple sclerosis (MS), and immunopathological studies have suggested a primary role of …

Abstract Objectives Intrathecally synthesized IgM can be seen not only in the cerebrospinal
fluid (CSF) in infectious and inflammatory diseases of the central nervous system, but also in …

Background: Intrathecal IgM synthesis is reported to be associated with a worse prognosis in
adults with multiple sclerosis (MS). Objective: To study the predictive value of intrathecal IgM …

Objective Intrathecal Immunoglobulin M synthesis (IgMIntrathecal Fraction (IF)+) and spinal
MRI lesions are both strong independent predictors of higher disease activity and severity in …

Objective We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal
synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting …