Apoptosis of HepG2 cells triggered by various agents is characterized in an attempt to
delineate the common apoptosis signaling pathway in human hepatoma cells. Several …

p53 and c-myc are both known to be involved in apoptotic cell death as well as positive or
negative regulation of cell proliferation, but it is not well established whether their functions …

The tumor suppressor p53 and the proto-oncogene Bcl-2 were two of the earliest identified
cancer genes. Mutant p53 proteins were first discovered in transformed murine cell lines, 1 …

The p53 tumor suppressor gene product can induce apoptotic cell death through an
unknown mechanism. Here we demonstrate that a temperature-sensitive p53 induces …

Abstract bcl-2 and p53 gene products have been both linked to programmed cell death
pathways. We have analyzed several human breast cancer cell lines for the expression of …

Using a temperature sensitive p53 construct (ts p53), we have earlier shown that expression
of wild-type (wt) p53 triggers apoptosis in a v-myc-induced T-cell lymphoma line that lacks …

We demonstrated that introduction and expression of wild-type p53 gene in the human
hepatocellular carcinoma cell line, Hep3B, resulted in up-regulation of both p21WAF1/CIP1 …

The p53 tumor suppressor protein can induce both apoptosis and cell cycle arrest.
Moreover, we and others have shown previously that p53 is a potent mediator of …

We review some of the most recent developments concerning three genes involved in
human cancer: p53, bcl2 and c-myc. Recent data have demonstrated that the bcl2 gene …

Recently, we have shown that the p53 tumor suppressor gene product can inhibit
expression of the bcl-2 gene. In this report, we explored the molecular basis for p53 …