[HTML][HTML] ROCK2 regulates monocyte migration and cell to cell adhesion in vascular endothelial cells
Y Takeda, K Matoba, D Kawanami, Y Nagai… - International journal of …, 2019 - mdpi.com
The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various
cellular functions, including organization of the actin cytoskeleton, cell adhesion and …
cellular functions, including organization of the actin cytoskeleton, cell adhesion and …
[HTML][HTML] ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
K Noma, Y Rikitake, N Oyama, G Yan… - The Journal of …, 2008 - Am Soc Clin Investig
Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …
[HTML][HTML] Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR−/− mice
HW Wang, PY Liu, N Oyama, Y Rikitake… - The FASEB …, 2008 - ncbi.nlm.nih.gov
Rho kinases (ROCKs) are serine-threonine protein kinases that regulate the actin
cytoskeleton. Recent studies suggest that ROCKs also play an important role in …
cytoskeleton. Recent studies suggest that ROCKs also play an important role in …
[HTML][HTML] Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-κB p65
H Shimada, LE Rajagopalan - Journal of biological chemistry, 2010 - ASBMB
Endothelial cells play an important role in the recruitment of immune cells to a disease locus
through the induced expression of chemokines and cell adhesion molecules (CAMs). The …
through the induced expression of chemokines and cell adhesion molecules (CAMs). The …
ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression
J Montalvo, C Spencer, A Hackathorn… - Current molecular …, 2013 - ingentaconnect.com
The serine/threonine protein kinase paralogs ROCK1 & 2 have been implicated as essential
modulators of angiogenesis; however their paralog-specific roles in endothelial function are …
modulators of angiogenesis; however their paralog-specific roles in endothelial function are …
Rho-associated protein kinase isoforms stimulate proliferation of vascular smooth muscle cells through ERK and induction of cyclin D1 and PCNA
Y Zhao, M Lv, HS Lin, Y Cui, XQ Wei, YH Qin… - Biochemical and …, 2013 - Elsevier
Abnormal proliferation and migration of vascular smooth muscle cells (VSMC) plays an
important role in vascular diseases. The Rho-associated protein kinase (ROCK) signaling …
important role in vascular diseases. The Rho-associated protein kinase (ROCK) signaling …
[HTML][HTML] Rho-associated coiled-coil kinase (ROCK) in molecular regulation of angiogenesis
J Liu, Y Wada, M Katsura, H Tozawa, N Erwin… - Theranostics, 2018 - ncbi.nlm.nih.gov
Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-
coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the …
coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the …
[HTML][HTML] ROCK1 promotes migration and invasion of non‑small‑cell lung cancer cells through the PTEN/PI3K/FAK pathway
C Hu, H Zhou, Y Liu, J Huang… - International …, 2019 - spandidos-publications.com
Rho‑associated protein kinase 1 (ROCK1), a member of the ROCK family, serves an
important function in cell migration and invasion in neoplasms. ROCK1 has been found to …
important function in cell migration and invasion in neoplasms. ROCK1 has been found to …
[HTML][HTML] Striking crosstalk of ROCK signaling with endothelial function
K Noma, Y Kihara, Y Higashi - Journal of cardiology, 2012 - Elsevier
Rho-associated coiled-coil forming protein kinases (ROCKs), the downstream target
proteins of RhoA, are ubiquitously expressed serine-threonine protein kinases. ROCKs have …
proteins of RhoA, are ubiquitously expressed serine-threonine protein kinases. ROCKs have …
Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis
Q Zhou, Y Mei, T Shoji, X Han, K Kaminski, GT Oh… - Circulation, 2012 - Am Heart Assoc
Background—Macrophages play a central role in the development of atherosclerosis.
However, the signaling pathways that regulate their function are not well understood. The …
However, the signaling pathways that regulate their function are not well understood. The …