Manganese (Mn) is an essential metalloenzyme component that in high doses can exert
serious oxidative and neurotoxic effects. The aim of this study was to investigate the …

Chronic exposure to manganese (Mn) leads to a neurological disorder referred to as
manganism, with pathological symptoms resembling those of Parkinson's disease (PD) …

Manganese (Mn) is an essential trace element that is naturally found in the environment and
is necessary as a cofactor for many enzymes and is important in several physiological …

An excessive activation of excitatory amino acid (EAA) receptors has been associated with
oxidative stress, which is considered the primary cause of manganese (Mn) poisoning …

Manganese (Mn) is one of the ubiquitous environmental pollutants that can induce an
indirect excitotoxicity caused by altered glutamate (Glu) metabolism. The present study has …

Manganese (Mn) exerts serious neurotoxic effects, among which, the disruption of the
glutamate/glutamine (Glu/Gln) cycle, leads to an excitotoxic insult. The molecular …

The objectives of this focused review are to (i) provide a systematic overview of recent
advances pertaining to the role of glia, namely microglia and astrocytes, in the …

Scope In industrial countries dietary manganese (Mn) intake is well above the estimated
average requirement. Moreover, exposure to high Mn levels is known to cause adverse …

Manganese (Mn) overexposure is a public health concern due to its widespread industrial
usage and the risk for environmental contamination. The clinical symptoms of Mn …

We have studied at the ultrastructural level the presence of manganese (Mn) in rat basal
ganglia, which are target regions of the brain for Mn toxicity. The rats underwent a moderate …