A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica

A Iyer, L Elsone, R Appleton, A Jacob - Autoimmunity, 2014 - Taylor & Francis
Neuromyelitis optica (NMO) is an immune-mediated neurological disorder characterised by
recurrent episodes of optic neuritis and longitudinally extensive transverse myelitis. A serum …

Current concept of neuromyelitis optica (NMO) and NMO spectrum disorders

A Jacob, A McKeon, I Nakashima, DK Sato… - Journal of Neurology …, 2013 - jnnp.bmj.com
Neuromyelitis optica (NMO) has been described as a disease clinically characterised by
severe optic neuritis (ON) and transverse myelitis (TM). Other features of NMO include …

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

SR Hinson, SF Roemer, CF Lucchinetti… - The Journal of …, 2008 - rupress.org
Neuromyelitis optica (NMO)-immunoglobulin G (IgG) is a clinically validated serum
biomarker that distinguishes relapsing central nervous system (CNS) inflammatory …

Optic neuritis in neuromyelitis optica

MH Levin, JL Bennett, AS Verkman - Progress in retinal and eye research, 2013 - Elsevier
Neuromyelitis optica (NMO) is an autoimmune demyelinating disease associated with
recurrent episodes of optic neuritis and transverse myelitis, often resulting in permanent …

Identification of two major conformational aquaporin-4 epitopes for neuromyelitis optica autoantibody binding

F Pisani, M Mastrototaro, A Rossi, GP Nicchia… - Journal of Biological …, 2011 - ASBMB
Neuromyelitis optica (NMO) is an autoimmune demyelinating disease characterized by the
presence of anti-aquaporin-4 (AQP4) antibodies in the patient sera. We recently reported …

Neuromyelitis optica spectrum disorder (NMOSD): A new concept

J De Seze, L Kremer, N Collongues - Revue neurologique, 2016 - Elsevier
The relationship between neuromyelitis optica (NMO) and multiple sclerosis (MS) has long
been controversial. NMO was previously considered a form of MS involving predominantly …

Neuromyelitis optica preceded by hyperCKemia episode

N Suzuki, T Takahashi, M Aoki, T Misu, S Konohana… - Neurology, 2010 - AAN Enterprises
Background: Neuromyelitis optica (NMO) is a disease of the CNS characterized by severe
optic neuritis and longitudinally extended transverse myelitis. Recent studies suggest that …

IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

VA Lennon, TJ Kryzer, SJ Pittock, AS Verkman… - The Journal of …, 2005 - rupress.org
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects
optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and …

Cytokines and chemokines in neuromyelitis optica: pathogenetic and therapeutic implications

A Uzawa, M Masahiro, S Kuwabara - Brain pathology, 2014 - Wiley Online Library
Neuromyelitis optica (NMO) is characterized by severe optic neuritis and longitudinally
extensive transverse myelitis. The discovery of an NMO‐specific autoantibody to the …

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

Y Guo, SD Weigand, BF Popescu, VA Lennon… - Acta …, 2017 - Springer
Pathogenic autoantibodies associated with neuromyelitis optica (NMO) induce disease by
targeting aquaporin-4 (AQP4) water channels enriched on astrocytic endfeet at blood–brain …