Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies

E Fonsatti, L Sigalotti, P Arslan… - Current Cancer Drug …, 2003 - ingentaconnect.com
Angiogenesis is crucial for tumor development and progression, and antiangiogenetic
therapy represents a promising approach for cancer treatment. Thus, the in-depth …

Endoglin (CD105): a target for anti-angiogenetic cancer therapy

E Fonsatti, M Altomonte, P Arslan… - Current drug targets, 2003 - ingentaconnect.com
Targeting of tumor vasculature is a promising strategy for cancer treatment. Among
endothelial cell markers, Endoglin, a cell membrane glycoprotein, is emerging as an …

Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels

E Fonsatti, M Altomonte, MR Nicotra, PG Natali, M Maio - Oncogene, 2003 - nature.com
Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as
a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane …

Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy

F Nassiri, MD Cusimano, BW Scheithauer… - Anticancer …, 2011 - ar.iiarjournals.org
Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and
its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been …

Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer

E Fonsatti, M Maio - Journal of translational medicine, 2004 - Springer
Antibody targeting of tumor-associated vasculature is a promising therapeutic approach in
human cancer; however, a specific cell membrane marker for endothelial cells of tumor …

CD105 is important for angiogenesis: evidence and potential applications

SE Duff, C Li, JM Garland, S Kumar - The FASEB Journal, 2003 - Wiley Online Library
Angiogenesis is the propelling force for tumor growth and metastasis, and antiangiogenic
therapy represents one of the most promising modalities for cancer treatment. CD105 …

Continuous endoglin (CD105) overexpression disrupts angiogenesis and facilitates tumor cell metastasis

C Ollauri-Ibáñez, E Núñez-Gómez, C Egido-Turrión… - Angiogenesis, 2020 - Springer
Endoglin (CD105) is an auxiliary receptor for members of the TFG-β superfamily. Whereas it
has been demonstrated that the deficiency of endoglin leads to minor and defective …

Organ‐specific endoglin (CD105) expression in the angiogenesis of human cancers

R Minhajat, D Mori, F Yamasaki, Y Sugita… - Pathology …, 2006 - Wiley Online Library
Some markers of angiogenic endothelial cells are emerging as targets for cancer therapy.
The present study compared the expression of CD105 with that of other endothelial markers …

Endoglin: an accessory component of the TGF‐β‐binding receptor‐complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

E Fonsatti, LD Vecchio, M Altomonte… - Journal of cellular …, 2001 - Wiley Online Library
Endoglin (CD105) is a cell membrane glycoprotein over‐expressed on highly proliferating
endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within …

Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers

R Minhajat, D Mori, F Yamasaki, Y Sugita, T Satoh… - Virchows Archiv, 2006 - Springer
Some markers of angiogenic endothelial cells are emerging as targets of cancer therapy.
The present study compares the expression of CD105 with that of other endothelial markers …