Transcription termination by RNA polymerase II (RNA Pol II) is linked to RNA 3′ end
processing by the cleavage and polyadenylation factor (CPF or CPSF). CPF contains …

Abstract The poly (A)(pA) signal possesses a dual function in 3′ end processing of pre-
mRNA and in transcriptional termination of RNA polymerase II (Pol II) for most eukaryotic …

Cleavage factor IA (CF IA), cleavage and polyadenylation factor (CPF), constitute major
protein complexes required for pre-mRNA 3′ end formation in yeast. The Clp1 protein …

At the 3′ ends of protein-coding genes, RNA polymerase (Pol) II is dephosphorylated at
tyrosine residues (Tyr1) of its C-terminal domain (CTD). In addition, the associated cleavage …

Polyadenylation is a co-transcriptional process that modifies mRNA 3′-ends in eukaryotes.
In yeast, CF IA and CPF constitute the core 3′-end maturation complex. CF IA comprises …

The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient
termination. A key player in this process is the cleavage and polyadenylation (CPA) factor …

Abstract Phosphorylation of serine-2 (S2) and serine-5 (S5) of the C-terminal domain (CTD)
of RNA polymerase II (RNAP II) is a dynamic process that regulates the transcription cycle …

Pcf11 is one of numerous proteins involved in pre-mRNA 3′-end processing and
transcription termination. Using elongation complexes (ECs) formed from purified yeast RNA …

Current models of transcription termination factor recruitment to the RNA polymerase II (Pol
II) transcription complex rely exclusively on the direct interaction between the termination …

Differently phosphorylated forms of RNA polymerase (Pol) II are required to guide the
enzyme through the transcription cycle. Here, we show that a phosphorylation …