The calcium sensing receptor (CaSR), a G-protein coupled receptor (GPCR), and its
downstream signalling pathways are essential for calcium homeostasis. Loss-or gain-of …

Adaptor protein-2 (AP2) is a heterotetramer of α, β, μ, and σ subunits that is pivotal in clathrin-
mediated endocytosis and facilitates internalisation of plasma membrane constituents such …

Abstract Adaptor protein 2 (AP2), a heterotetrameric complex comprising AP2α, AP2β2,
AP2μ2 and AP2σ2 subunits, is ubiquitously expressed and involved in endocytosis and …

The adaptor protein-2 sigma subunit (AP2σ2) is pivotal for clathrin-mediated endocytosis of
plasma membrane constituents such as the calcium-sensing receptor (CaSR). Mutations of …

The Adaptor Protein 2 (AP2) is a heterotetrameric complex comprising of α, β, μ and σ-
subunits, and it has an integral role in clathrin-mediated endocytosis (CME). CME is the …

Familial hypocalciuric hypercalcaemia type-3 (FHH3) is caused by loss-of-function
mutations of the sigma subunit of adaptor protein-2 (AP2), a ubiquitously expressed …

The calcium sensing receptor (CaSR) is a G-protein coupled receptor (GPCR) that plays a
central role in calcium homeostasis. Loss-of-function mutations of the CaSR cause familial …

The calcium-sensing receptor (CaSR), a class C G-protein coupled receptor (GPCR) is
critical for calcium homeostasis. The presence of CaSR at the plasma membrane (PM) is …

Familial hypocalciuric hypercalcaemia (FHH) is an autosomal dominant disorder
characterized by lifelong elevation of serum calcium concentrations with inappropriately low …

Mutations of the sigma subunit of the heterotetrameric adaptor-related protein complex 2
(AP2σ) impair signalling of the calcium-sensing receptor (CaSR), and cause familial …