Introduction: Medical cannabis (MC) is commonly claimed to be an effective treatment for
chronic or refractory pain. With interest in MC in the United States growing, as evidenced by …

Objective: To review the literature concerning the physiology of the endocannabinoid
system, current drug development of cannabinoid agonists, and current clinical research on …

Neuropathic pain is a debilitating form of chronic pain resulting from nerve injury, disease
states, or toxic insults. Neuropathic pain is often refractory to conventional …

Background There are conflicting interpretations of the evidence regarding the efficacy,
tolerability, and safety of cannabinoids in pain management and palliative medicine …

Objective To determine if medical marijuana provides pain relief for patients with chronic
noncancer pain (CNCP) and to determine the therapeutic dose, adverse effects, and specific …

Cannabinoids show promise as therapeutic agents, particularly as analgesics, but their
development and clinical use has been complicated by recognition of their botanical source …

Abstract Purpose of Review Cannabis has been used since ancient times for medical and
recreational research. This review article will document the validity of how medical cannabis …

Objective To determine the effects of medical cannabinoids on pain, spasticity, and nausea
and vomiting, and to identify adverse events. Data sources MEDLINE, the Cochrane …

Background There is considerable public and political interest in the use of cannabis
products for medical purposes. Methods The task force of the European Pain Federation …

Abstract Treatment of neuropathic pain (NP) symptoms associated with multiple sclerosis
(MS) is frequently insufficient. Yet, cannabis is still rarely offered for treatment of pain. This …