The chemical synthesis of proteins provides synthetic chemists with an interesting challenge
and supports biological research through the generation of proteins that are not produced …

This review describes current methods for peptide and protein syntheses, largely from a
strategic point of view. The solid phase method is useful for the rapid preparation of …

Organic chemists working on the synthesis of natural products have long found a special
challenge in the preparation of peptides and proteins. However, more reliable, more efficient …

The chemical synthesis of peptides or small proteins is often an important step in many
research projects and has stimulated the development of numerous chemical …

In these studies we have shown that reaction of a peptide-α-thioacid with an aryl disulfide
gives a product with mass consistent with a 1-acyl-2-aryl disulfide species as the initial …

The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

The progress of total chemical protein synthesis has been hampered by difficulties in
preparing peptide thioesters by standard Fmoc peptide synthesis. The amino acid, α …

C-terminal peptide α-thioesters are valuable intermediates in the synthesis/semisynthesis of
proteins by native chemical ligation. They are prepared either by solid-phase peptide …

An efficient new strategy for the synthesis of peptide and glycopeptide thioesters is
described. The method relies on the side‐chain immobilization of a variety of Fmoc‐amino …

Total chemical synthesis of proteins has been rendered practical by the chemical ligation
principle: chemoselective condensation of unprotected peptide segments equipped with …