Apoptosis in sepsis
R Mahidhara, TR Billiar - Critical care medicine, 2000 - journals.lww.com
Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …
infection. Previous models have focused on the mechanisms which upregulate and sustain …
[HTML][HTML] Simultaneous activation of apoptosis and inflammation in pathogenesis of septic shock: a hypothesis
VD Joshi, DV Kalvakolanu, AS Cross - FEBS letters, 2003 - Elsevier
Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …
result from uncontrolled inflammatory responses to microbial infection and/or components …
Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets
A Ayala, M Perl, F Venet, J Lomas-Neira… - Current …, 2008 - ingentaconnect.com
The inability of present therapies to mitigate the devastating effects of sepsis and multiple
organ failure in the critically ill patient indicates that more knowledge of the pathophysiology …
organ failure in the critically ill patient indicates that more knowledge of the pathophysiology …
Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis
A Ayala, DE Wesche‐Soldato, M Perl… - Sepsis: New Insights …, 2006 - Wiley Online Library
Over time it has become clear that, much like other organ systems, the function and
responsiveness of the immune system is impaired during the course of sepsis and that this is …
responsiveness of the immune system is impaired during the course of sepsis and that this is …
Role of apoptotic cell death in sepsis
RS Hotchkiss, KW Tinsley, IE Karl - Scandinavian journal of …, 2003 - Taylor & Francis
Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …
Cellular apoptosis and organ injury in sepsis: a review
C Power, N Fanning, HP Redmond - Shock, 2002 - journals.lww.com
Apoptosis, as a biological phenomenon, is readily identifiable by several characteristic
features. It characteristically affects scattered single cells, not groups of contiguous cells as …
features. It characteristically affects scattered single cells, not groups of contiguous cells as …
Prevention of lymphocyte apoptosis—a potential treatment of sepsis?
RS Hotchkiss, CM Coopersmith… - Clinical Infectious …, 2005 - academic.oup.com
Sepsis is the leading cause of death in surgical intensive care units and is a major cause of
morbidity and mortality in neonatal and medical intensive care units. The Centers for …
morbidity and mortality in neonatal and medical intensive care units. The Centers for …
The role and regulation of apoptosis in sepsis
DE Wesche-Soldato, JL Lomas-Neira… - Journal of …, 2005 - journals.sagepub.com
Today, sepsis continues to be a growing problem in the critically ill patient population. A
number of laboratories have been interested in understanding how changes in immune cell …
number of laboratories have been interested in understanding how changes in immune cell …
Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target?
A Oberholzer, C Oberholzer, RM Minter, LL Moldawer - Immunology Letters, 2001 - Elsevier
Treatment of sepsis and septic shock remains a clinical conundrum. Recent prospective
trials with anti-cytokine and anti-inflammatory therapies have shown only modest clinical …
trials with anti-cytokine and anti-inflammatory therapies have shown only modest clinical …
The apoptotic pathway as a therapeutic target in sepsis
DE Wesche-Soldato, RZ Swan, CS Chung… - Current drug …, 2007 - ingentaconnect.com
Recent research has yielded many interesting and potentially important therapeutic targets
in sepsis. Specifically, the effects of antagonistic anti-cytokine therapies (tumor necrosis …
in sepsis. Specifically, the effects of antagonistic anti-cytokine therapies (tumor necrosis …