Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …

The inability of present therapies to mitigate the devastating effects of sepsis and multiple
organ failure in the critically ill patient indicates that more knowledge of the pathophysiology …

Over time it has become clear that, much like other organ systems, the function and
responsiveness of the immune system is impaired during the course of sepsis and that this is …

Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …

Apoptosis, as a biological phenomenon, is readily identifiable by several characteristic
features. It characteristically affects scattered single cells, not groups of contiguous cells as …

Today, sepsis continues to be a growing problem in the critically ill patient population. A
number of laboratories have been interested in understanding how changes in immune cell …

Sepsis is the leading cause of death in surgical intensive care units and is a major cause of
morbidity and mortality in neonatal and medical intensive care units. The Centers for …

Treatment of sepsis and septic shock remains a clinical conundrum. Recent prospective
trials with anti-cytokine and anti-inflammatory therapies have shown only modest clinical …

Recent research has yielded many interesting and potentially important therapeutic targets
in sepsis. Specifically, the effects of antagonistic anti-cytokine therapies (tumor necrosis …